Linear regression was selected as the statistical method of data analysis. This, EDSS is still accepted and preferred as the main disability-outcomeĭescriptive statistics were used to calculate median age, EDSS, fatigue and Inter- and intra-rater reliability and sensitivity to change. 17 Some of the limitations regarding EDSS include documented weakness in On the evaluation of eight functional systems of the CNS. The score is assessed by a clinician based Restricts its focus on the health-related area of life quality.ĮDSS is a measure of disability. While the term quality of life may include a broad range of elements, this study 4 Moreover, it is well-studied among MS-patients, 4 and has therefore been selected as the QOL-outcome-measure. Used generic instrument and is considered to be the golden standard in measuring The SF-36 consists of eight dimensions (physical functioning, role limitationsĬaused by physical problems, bodily pain, general health, vitality, socialįunctioning, role limitation caused by emotional problems and mental health).Įach area is individually scored and transformed into a scale ranging from 0 SF-36 is a tool measuring perceived health status, and is not specific for MS. Monitored: FSMC quantifies fatigue itself, whereas MFIS additionally focuses on 14, 15 This scale has been defined as one of the mostīoth scales were examined simultaneously because of the different aspects A score of 38 points is categorized asįatigue. MFIS consists of 21 items (9 for motor, 10 for cognition Īnd 2 for psychosocial fatigue ) with 0–4 points per item. 11 The scale has undergone validation based on a large sample of patients, 11 and also the Danish translation has been validated. ≥53 as moderate fatigue and ≥63 as severe fatigue.
A sum score of ≥43 is categorized as mild fatigue, Motor fatigue ) with 1–5 points per item. Investigate whether this impact exists independently of bodily disability.įSMC consists of 20 items (10 for cognitive fatigue and 10 for Impact of motor and cognitive fatigue on different aspects of QOL separately, and to The aim of this study is therefore to examine the This has only been examined inĪ few studies, 9 – 11 pointing towards the need forįurther research in this field. Step towards improving current treatment strategies. 8 This will contribute to a better understanding of the complex nature ofįatigue and the role it plays in the daily life of MS patients, which is the first Unidimensional views of fatigue and QOL are obsolete, emphasizing the need forĮxamining cognitive and motor fatigue, as well as mental and physical QOL, separately. Studies have examined the relation between overall fatigue and QOL. Role in relation to QOL among MS patients than physical disability itself. This incites the question of whether the experience of fatigue plays a more crucial 1 Due to the multiple types and causes of fatigue, treatment of this symptom CentralĪbnormalities, inflammation and immunological factors have been found to play a role. 1 The pathophysiology of primary fatigue remains unknown.
Or cognitive fatigue, or as primary fatigue (specific to MS) or secondary fatigue 1 MS-related fatigue can be categorized due to its presentation as either motor Interferes most with everyday life by up to 55%. MS-patients, affecting up to 80% of all patients and classified as the symptom which 2 Nonetheless, QOL is a subjective measure and might not always reflect anĪctual change in disease characteristics, pointing out the need for a combination ofįatigue is often reported as the most frequent and disabling symptom among The neurological disability, pointing out the inadequacy of disease monitoring withĮDSS-scores solitarily. 4 Studies have shown that this reduction in QOL can only partly be explained by Nature of the disease course, diffuse symptoms and lack of proper treatment. 2 This might be due to onset in early years of adulthood, the unpredictable Reduced QOL compared to the general population. QOL includes information on several aspects of life such as overall well-being, Quality of life (QOL) measurement is an alternative way to examine the impact of MS. Has been criticized for its overemphasis on motor and gait function. 1 Disability status among MS patients is most commonly measured with theĮxpanded Disability Status Scale (EDSS), which quantifies the severity of disabilityĪnd is useful for objective monitoring of disease progression, although this tool Multiple Sclerosis (MS) is a chronic, neurological illness characterized byĪutoimmune-induced demyelination of nerves in CNS leading to different degrees of disability.
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